Placental malaria (PM) is a leading cause of maternal and infant mortality.Although the accumulation of parasitized erythrocytes (PEs) and monocytes within the placenta is thought to contribute to the pathophysiology of PM, the molecular mechanisms underlying PM remain unclear.Based on the hypothesis that excessive complement activation may contrib
Denosumab, a human monoclonal antibody against RANK ligand, is shown to have strong anti-fracture effects in Japanese osteoporosis patients.However, there have been no data showing actions on Japanese bone architecture.Here we show that denosumab continuously improves several geometrical parameters calculated by hip structural analysis for 3 years.
In 1948 a corticosteroid compound was administered for the first time to a patient affected by rheumatoid arthritis by Philip Showalter Hench, a rheumatologist at the Mayo Colormotion Clinic in Rochester, Minnesota (USA).He was investigating since 1929 the role of adrenal gland-derived substances in rheumatoid arthritis.For the discovery of cortiso
Plantations with fast growing exotic tree species can negatively affect native plant species diversity and promote the spread of alien species.Mediterranean Chile experienced major landscape changes with a vast expansion of industrial plantations of Pinus radiata in the past.However, with increasing knowledge of biodiversity effects on ecosystem se